Exaggerate succynilcholine-type muscle relaxation during anesth. Patients w/ sick sinus syndrome or other supraventricular cardiac conduction conditions eg, SA or AV block. Frequent dosing w/ 10 mg/day produce diarrhea, nausea, & vomiting. Monitor closely for symptoms of active or occult GI bleeding, especially those at increased risk of developing ulcers eg, those w/ history of ulcer disease or receiving concurrent NSAIDs. May cause bladder outflow obstruction. Potential to cause generalized convulsions; to exacerbate or induce extrapyramidal symptoms. History of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other inhibitors of acetylcholinesterase, agonists or antagonists of the cholinergic system. Severe hepatic impairment. Lactation. Not recommended for childn.
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